 |
III International Course on Microarray Data
Analysis
Centro de Investigación
Príncipe Felipe, Valencia.
March 12-16, 2007
A five days theoretical and practical course on microarray data
analysis oriented to experimentalists, end-users and PhD students who
want to learn about the state-of-the-art of the data analysis
methodologies in this fast changing area. The course will allow the
students to acquire the skills necessary for analysing their own data
using one of the most advanced software packages, the GEPAS, to
obtaining a significant functional interpretation of their results
suing the innovative Babelomics suite for functional profiling, and
to go even beyond and addressing complex problems using the popular
Bioconductor tools.
Organized by
Joaquín
Dopazo, Fátima Al-Shahrour, David Montaner
Department of Bioinformatics and Functional Genomics Node (INB)
Centro de Investigación Príncipe Felipe (CIPF)
46013, Valencia, Spain
Teachers
Fátima
Al-Shahrour, Lucía Conde, Joaquín Dopazo, Jaime
Huerta, David Montaner, Pablo Mínguez, Ignacio Medina, Susana
Vega, Kasper Henses
Bioinformatics Department, CIPF, Valencia.
Summary
DNA microarrays constitute, no doubt, a paradigm among post-genomic
technologies, which are characterised for producing large amounts of
data, whose analysis and interpretation is not trivial. Microarray
technologies allows querying living systems in a completely new way,
but at the same time present new challenges in the way hypotheses must
be tested and our results ought to be analysed.
Since the first papers published in the latest nineties the number of
questions that have been addressed through this technique have both
increased and diversified. Initial interest was focused on genes
co-expressing across sets of experimental conditions, implying
essentially the use of clustering techniques. More recently, however,
the interest has switched to find genes differentially expressed among
distinct classes of experiments, or correlated to diverse
parameters. There is also much interest in robust methods for building
predictors of clinical outcomes. Also, CGH-arrays (Albertson and
Pinkel, 2003) are recently becoming an alternative for studying the
relationship between chromosomal alterations affecting to copy number
(which are behind many diseases) and gene expression. In addition,
there is also a clear demand for methods that allow automatic transfer
of biological information to the results of microarray experiments and
to interpret them at the light of the biological knowledge. Recently,
new methods of analysis have been proposed that directly address
hypothesis on blocks of genes functionally related that have
demonstrated to be superior to the classical one-gene-at-a-time
approaches (Mootha et al., 2003; Al-Shahrour et al., 2005)
This course covers the state-of-the-art in the above mentioned topics,
which are of major relevance in today?s gene expression data
analysis. Through sessions of theory and practical examples, the
students will acquire the experience necessary to address scientific
questions to gene expression array datasets and solve them. Special
attention will be devoted to important (although not always took into
account) aspects in microarray data analysis, such as multiple testing
or functional profiling. In addition, some theoretical lessons on
basic statistics will be included as part of the programme. Finally,
for the bravest and those who want to go in more depth into analysis
possibilities, the last day a short course on Bioconductor (Gentleman
et al., 2004) will be taught.
The course is designed to be a mixture of theoretical and practical
sessions. The latter will require some familiarity with the use of
web-based tools and knowledge of basics notions of statistics.
Practical sessions will be carried out using the GEPAS (Herrero et
al., 2003, 2004, Vaquerizas et al., 2005; Montaner et al., 2006)
environment, an integrated web tool for microarray data analysis, and
the Babelomics suite (Al-Shahrour et al., 2005b, 2006) for functional
profiling of genome-scale experiments.
The course will be held the week before fallas, one of the most
popular and impressing folkloric festivals in Spain which en the 19th
March when all the fallas are burn in an apotheosis of fireworks. So
you can use this opportunity to enjoy one of the most exceptional
holiday festival in the world.
More info
|
|
