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Programas RTICC » Cáncer de colon » Introducción
 
INTRODUCTION

Colon cancer is the third most common cancer and the second cause of cancer death in developed countries. Colorectal cancer (CRC), when men and women are considered together, is the most frequent cancer in Spain, where every year more than 19,000 new cases are diagnosed. Nowadays, the life-time cumulative risk is about 6% and overall 5-year survival is around 50%, but this depends enormously on the stage at diagnosis. Prognosis is very poor for stage IV (20%), and these patients are treated with different lines of chemotherapy and targeted therapies than involve anti VEGF and EGFR treatments which are very expensive to the health care system. Pancreatic ductal adenocarcinoma is one of the most aggressive cancers and remains a largely incurable disease. It represents about 10% of all gastrointestinal malignancies, and it is the fourth leading cause of cancer death overall. It is the tumor in which less progress has been made at the clinical level in the last 50 years. Gastric cancer is currently the 5th leading cause of cancer-related death in both sexes, with rates of 12.94 and 5.65 in men and women, respectively in Spain with important geographic differences: some Spanish regions present mortality rates that are much higher than the European mean, while others show rates among the lowest in the continent. + more...

OBJECTIVES

EXCELLENCE, INNOVATION AND TECHNOLOGY TRANSFER

FUNCTIONAL STRUCTURE OF THE PROGRAMME

SYNERGIES

ADDED VALUE OF THE RESEARCH GROUPS

MANAGEMENT OF THE PROGRAM

IMPACT AND TRANSFER

SCHEME OF EVALUATION OF THE PROGRAMME

Timeline of tasks related to specific WPs

Introducción
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03/03/2017 | Otras reuniones
13/11/2016 | Otras reuniones
Publicaciones
RD12/0036/0053
Adherence to capecitabine in preoperative treatment of stage II and III rectal cancer: do we need to worry?
Font R, Espinas JA, Layos L, Martinez Villacampa M, Capdevila J, Tobeña M, Pisa A, Pericay C, Lezcano C, Fort E, Cardona I, Berga N, Solà J, Borras JM
Ann Oncol  2017.  4.  831-835.  PMID: 28327898. 

RD12/0036/0053
Understanding variations in the use of hypofractionated radiotherapy and its specific indications for breast cancer: A mixed-methods study.
Prades J, Algara M, Espinàs JA, Farrús B, Arenas M, Reyes V, García-Reglero V, Cambra MJ, Rubio E, Anglada L, Eraso A, Pedro A, Fuentes-Raspall MJ, Tuset V, Solà J, Borras JM
Radiother Oncol  2017.  1.  22-28.  PMID: 28236538. 

RD12/0036/0053
Current developments in cancer care: including the patients' perspective-3rd European Roundtable Meeting (ERTM) June 17, 2016, Berlin, Germany.
Ortmann O, Rösler W, Helbig U, participants of the ERTM.
J Cancer Res Clin Oncol  2017.  4.  673-676.  PMID: 27988842. 

RD12/0036/0005
Snail1-expressing fibroblasts as a source of paracrine signals in colon cancer tumors
Herrera A, Herrera M, Alba-Castellón L, Silva J, García V, Loubat J, Alvarez-Cienfuegos A, García JM, Rodríguez R, Gil B, Citores MJ, Larriba MJ, Casal JI, García de Herreros A, Bonilla F, Peña C
  2014. 
Grupos colaboradores: RD12/0036/0005 , RD12/0036/0041

RD12/0036/0005
The Epithelial-to-Mesenchymal Transition (EMT), a Particular Case.
Cebrià-Costa JP, Millanes-Romero A, de Herreros AG, Peiró S
Mol Cell Oncol  2014.  2.  e960770.  PMID: 27308335. 

RD12/0036/0005
Snail1 controls cooperative cell plasticity during metastasis.
Baulida J
Oncoscience  2015.  11.  898-9.  PMID: 26697515. 

RD12/0036/0005
Lysyl oxidase-like 2 (LOXL2) oxidizes trimethylated lysine 4 in histone H3.
Herranz N, Dave N, Millanes-Romero A, Pascual-Reguant L, Morey L, Díaz VM, Lórenz-Fonfría V, Gutierrez-Gallego R, Jerónimo C, Iturbide A, Di Croce L, García de Herreros A, Peiró S
FEBS J  2016.  23.  4263-4273.  PMID: 27735137. 

RD12/0036/0005
Pharmacological Approaches in an Experimental Model of Non-Small Cell Lung Cancer: Effects on Tumor Biology.
Mateu-Jimenez M, Fermoselle C, Rojo F, Mateu J, Peña R, Urtreger AJ, Diament MJ, Joffé ED, Pijuan L, Herreros AG, Barreiro E
Curr Pharm Des  2016.  34.  5300-5310.  PMID: 27339432. 
Grupos colaboradores: RD12/0036/0005 , RD12/0036/0051

RD12/0036/0005
Snail1-Dependent Activation of Cancer-Associated Fibroblast Controls Epithelial Tumor Cell Invasion and Metastasis.
Alba-Castellón L, Olivera-Salguero R, Mestre-Farrera A, Peña R, Herrera M, Bonilla F, Casal JI, Baulida J, Peña C, García de Herreros A
Cancer Res  2016.  21.  6205-6217.  PMID: 27503928. 
Grupos colaboradores: RD12/0036/0005 , RD12/0036/0041

RD12/0036/0005
Antisense non-coding RNAs and regulation of gene transcription.
Beltran M, García de Herreros A
Transcription  2016.  2.  39-43.  PMID: 26985653. 

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