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RETICS OBJECTIVES: THEIR RELEVANCE FOR THE OBJECTIVES FOR THE HEALTH STRATEGIC ACTION

The current proposal for an ISCIII-sponsored RETIC on cancer for the period 2013-2016 reflects the natural evolution of prior experiences of cooperative cancer research networks previously held in Spain on a continuous basis since 2003. In particular, an initial Network of Cancer Research Centers (Red Temática de Investigación Cooperative de Centros de Cancer, RTICCC) was established during the years 2003-2006 that encompassed 23 separate institutions research centers (126 individual groups) located in different hospitals and research centers located of 12 different autonomous regions of Spain. Since 2006, the Spanish Cancer Network switched focus from the research centers to the individual lPI-led groups and a new Red Temática de Investigación Cooperativa en Cancer, RTICC, was established that involved the cooperative work of 95 distinct, PI-led groups (85 Regular groups, and 15 clinical associate groups) distributed in institutions located in 13 different CCAA of this country. Despite its initial conception as 4 year project, the ISCIII has extended the activities and validity of the current RTICC has extended its activities for a total 6 years, until the end of 2012. The current proposal for a new RETIC on cancer is being presented by the 20-member Executive Committee of the current RTICC, in an effort to extend and improve on the quality and results yields of the research efforts of the Cancer research cooperative in our country.

It is also pertinent to mention that the Strategic Action Plan presented in this document represents a natural continuation of the Strategic Action Plans that were implemented and refined periodically in the RTICC network in response to the yearly evaluations and recommendations received during the period 2007-2012 from either ad hoc external evaluation agencies commissioned by ISCIII or from its own external Scientific Advisory Board. As many of those recommendations were geared at improving the scientific quality and international competitiveness of the RTICC network components, the current proposal reflects an emphasis on (i) the translational orientation of basic, clinical and epidemiological research tasks planned for the network as well as on (ii) the lower number, (iii) bigger size and (iv)higher scientific productivity of the groups selected to participate in this initiative. In this regard it is worth mentioning that the list of groups participating in the current proposal is composed by (i) a majority (about 80%) of RTICC groups that were consistently evaluated in the top 50% of that network and a (ii) smaller group (about 15%) of new, high quality research groups that were not previously part of RTICC as they were integrated in research structures (such as Consoliders) that were deemed incompatible with the RETICs by ISCIII (to which they have now resigned).

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03/03/2017 | Otras reuniones
13/11/2016 | Otras reuniones
Publicaciones
RD12/0036/0053
Adherence to capecitabine in preoperative treatment of stage II and III rectal cancer: do we need to worry?
Font R, Espinas JA, Layos L, Martinez Villacampa M, Capdevila J, Tobeña M, Pisa A, Pericay C, Lezcano C, Fort E, Cardona I, Berga N, Solà J, Borras JM
Ann Oncol  2017.  4.  831-835.  PMID: 28327898. 

RD12/0036/0053
Understanding variations in the use of hypofractionated radiotherapy and its specific indications for breast cancer: A mixed-methods study.
Prades J, Algara M, Espinàs JA, Farrús B, Arenas M, Reyes V, García-Reglero V, Cambra MJ, Rubio E, Anglada L, Eraso A, Pedro A, Fuentes-Raspall MJ, Tuset V, Solà J, Borras JM
Radiother Oncol  2017.  1.  22-28.  PMID: 28236538. 

RD12/0036/0053
Current developments in cancer care: including the patients' perspective-3rd European Roundtable Meeting (ERTM) June 17, 2016, Berlin, Germany.
Ortmann O, Rösler W, Helbig U, participants of the ERTM.
J Cancer Res Clin Oncol  2017.  4.  673-676.  PMID: 27988842. 

RD12/0036/0005
Snail1-expressing fibroblasts as a source of paracrine signals in colon cancer tumors
Herrera A, Herrera M, Alba-Castellón L, Silva J, García V, Loubat J, Alvarez-Cienfuegos A, García JM, Rodríguez R, Gil B, Citores MJ, Larriba MJ, Casal JI, García de Herreros A, Bonilla F, Peña C
  2014. 
Grupos colaboradores: RD12/0036/0005 , RD12/0036/0041

RD12/0036/0005
The Epithelial-to-Mesenchymal Transition (EMT), a Particular Case.
Cebrià-Costa JP, Millanes-Romero A, de Herreros AG, Peiró S
Mol Cell Oncol  2014.  2.  e960770.  PMID: 27308335. 

RD12/0036/0005
Snail1 controls cooperative cell plasticity during metastasis.
Baulida J
Oncoscience  2015.  11.  898-9.  PMID: 26697515. 

RD12/0036/0005
Lysyl oxidase-like 2 (LOXL2) oxidizes trimethylated lysine 4 in histone H3.
Herranz N, Dave N, Millanes-Romero A, Pascual-Reguant L, Morey L, Díaz VM, Lórenz-Fonfría V, Gutierrez-Gallego R, Jerónimo C, Iturbide A, Di Croce L, García de Herreros A, Peiró S
FEBS J  2016.  23.  4263-4273.  PMID: 27735137. 

RD12/0036/0005
Pharmacological Approaches in an Experimental Model of Non-Small Cell Lung Cancer: Effects on Tumor Biology.
Mateu-Jimenez M, Fermoselle C, Rojo F, Mateu J, Peña R, Urtreger AJ, Diament MJ, Joffé ED, Pijuan L, Herreros AG, Barreiro E
Curr Pharm Des  2016.  34.  5300-5310.  PMID: 27339432. 
Grupos colaboradores: RD12/0036/0005 , RD12/0036/0051

RD12/0036/0005
Snail1-Dependent Activation of Cancer-Associated Fibroblast Controls Epithelial Tumor Cell Invasion and Metastasis.
Alba-Castellón L, Olivera-Salguero R, Mestre-Farrera A, Peña R, Herrera M, Bonilla F, Casal JI, Baulida J, Peña C, García de Herreros A
Cancer Res  2016.  21.  6205-6217.  PMID: 27503928. 
Grupos colaboradores: RD12/0036/0005 , RD12/0036/0041

RD12/0036/0005
Antisense non-coding RNAs and regulation of gene transcription.
Beltran M, García de Herreros A
Transcription  2016.  2.  39-43.  PMID: 26985653. 

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